English giants Arsenal, meanwhile, will have to overcome Turkish side Fenerbahce if they are to reach the group stages of the competition.
Elsewhere, Olympique Lyonnais meet last year's Primera Division surprise package Real Sociedad, while Schalke take on Ukrainian side Metalist Karkiv and Pacos Ferreira face Zenit St Petersburg in the fifth and last tie of the league route.
In the Champions Route, Scottish champions Celtic will have to deal with Kazakhstan title-holdersShakhter Karagandy, while last year's Europa League semi-finalists Basel were paired with Ludogoretsof Bulgaria.
The first leg of the play-offs will be held on August 20-21, with the returns scheduled to take place one week later. Teams drawn first will play the first leg at home.
The 10 winners of the play-off round ties join 22 automatic entrants in the group stage draw in Monaco on 29 August.
